Ichizuka Kiyotake, Matsuoka Ryu, Aoki Hiroko, Hasegawa Junichi, Okai Takashi, Umemura Shin-Ichiro
Department of Obstetrics and Gynecology, Showa University Northern Yokohama Hospital, Chigasaki-chuo, Tsuzuki-ku, Yokohama, Kanagawa, 224-8503, Japan.
Department of Obstetrics and Gynecology, Showa University, School of Medicine, Tokyo, Japan.
J Med Ultrason (2001). 2016 Oct;43(4):487-92. doi: 10.1007/s10396-016-0725-x. Epub 2016 Jun 9.
The objective of the present study was to develop a high-intensity focused ultrasound (HIFU) transducer more suitable for clinical use in fetal therapy for twin reversed arterial perfusion (TRAP) sequence.
We created a cooling and degassed water-circulating-type HIFU treatment device. HIFU was applied to renal branch vessels in three rabbits. Sequential HIFU irradiation contains a trigger wave, heating wave, and rest time. The duration of HIFU application was 10 s/course. Targeting could be achieved by setting the imaging probe in the center and placing the HIFU beam and imaging ultrasonic wave on the same axis.
We confirmed under sequential HIFU irradiation with a total intensity of 1.94 kW/cm(2) (spatial average temporal average intensity) that the vein and artery were occluded in all three rabbits.
Simultaneous occluding of the veins and arteries was confirmed with trigger waves and a resting phase using the HIFU transducer treatment device created for this study. Clinical application appears possible and may represent a promising option for fetal therapy involving TRAP sequence.
本研究的目的是开发一种更适合用于双胎反向动脉灌注序列（TRAP）胎儿治疗临床应用的高强度聚焦超声（HIFU）换能器。
我们制造了一种冷却和脱气水循环式HIFU治疗装置。对三只兔子的肾分支血管施加HIFU。连续HIFU照射包括触发波、加热波和休息时间。HIFU应用持续时间为10秒/疗程。通过将成像探头置于中心并使HIFU束和成像超声波位于同一轴上可实现靶向。
我们证实在总强度为1.94kW/cm²（空间平均时间平均强度）的连续HIFU照射下，三只兔子的静脉和动脉均被阻塞。
使用为本研究制造的HIFU换能器治疗装置，通过触发波和休息期证实了静脉和动脉的同时阻塞。临床应用似乎可行，可能是涉及TRAP序列胎儿治疗的一个有前景的选择。
