获取低复杂度结构域修饰的方法。

Getting Access to Low-Complexity Domain Modifications.

机构信息

Department of Molecular Epigenetics, Helmholtz Center Munich and Center for Integrated Protein Science Munich (CIPSM), Marchioninistrasse 25, 81377 Munich, Germany.

出版信息

Trends Biochem Sci. 2016 Nov;41(11):894-897. doi: 10.1016/j.tibs.2016.05.010. Epub 2016 Jun 6.

DOI:10.1016/j.tibs.2016.05.010

PMID:27283512

Abstract

Low-complexity (LC) domains regulate the aggregation and phase transition of proteins in a modification-dependent manner. The study of LC domain modifications has now become feasible, as shown by genetic variants of the carboxy-terminal domain (CTD) of RNA Polymerase II (Pol II) that provide access to the type and position of modifications of a LC domain by mass spectrometry (MS).

摘要

低复杂度（LC）结构域以依赖修饰的方式调节蛋白质的聚集和相变。RNA 聚合酶 II（Pol II）羧基末端结构域（CTD）的遗传变异表明，LC 结构域修饰的研究现在已经成为可能，这些遗传变异可通过质谱（MS）获取 LC 结构域修饰的类型和位置。