Kouzu Keita, Tsujimoto Hironori, Hiraki Shuichi, Horiguchi Hiroyuki, Nomura Shinsuke, Ito Nozomi, Kanematsu Kyohei, Yamazaki Kenji, Aosasa Suefumi, Yamamoto Junji, Hase Kazuo
Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
Mol Clin Oncol. 2016 Jun;4(6):976-982. doi: 10.3892/mco.2016.843. Epub 2016 Mar 31.
Elderly patients are often considered as high-risk for major abdominal surgery due to reduced functional reserve and increased comorbidities. We herein evaluated the efficacy of totally laparoscopic distal gastrectomy (TLDG) in elderly patients with gastric cancer by measuring the postoperative systemic responses and postoperative analgesic consumption. A total of 102 patients with gastric cancer [57 who underwent TLDG and 45 who underwent laparoscopy-assisted distal gastrectomy (LADG)] were enrolled in this study. The patients were classified as elderly (aged ≥75 years) and non-elderly (aged <75 years) groups. The surgical outcome and postoperative analgesic consumption were evaluated. The elderly group exhibited a higher incidence of comorbidities and a longer postoperative hospital stay compared with those of younger patients, although there was no difference in the incidence of postoperative complications. In addition, the total consumption of additional analgesics until postoperative day 5 in patients who underwent TLDG was significantly lower compared with that in patients who underwent LADG in the elderly group; there was no such difference in the non-elderly group. The results suggested that TLDG was better for the management of postoperative pain in elderly patients with gastric cancer, who exhibit the highest mortality rates in the adult surgical population.
由于功能储备减少和合并症增加,老年患者常被视为腹部大手术的高危人群。我们在此通过测量术后全身反应和术后镇痛药物消耗量,评估了全腹腔镜远端胃癌切除术(TLDG)对老年胃癌患者的疗效。本研究共纳入102例胃癌患者[57例行TLDG,45例行腹腔镜辅助远端胃癌切除术(LADG)]。患者被分为老年组(年龄≥75岁)和非老年组(年龄<75岁)。评估手术结果和术后镇痛药物消耗量。老年组合并症发生率较高,术后住院时间较长,尽管术后并发症发生率无差异。此外,老年组中,行TLDG的患者至术后第5天的额外镇痛药物总消耗量显著低于行LADG的患者;非老年组无此差异。结果表明,TLDG对老年胃癌患者术后疼痛的管理效果更好,而老年胃癌患者在成人手术人群中的死亡率最高。