Watterson Lucas R, Kufahl Peter R, Taylor Sara B, Nemirovsky Natali E, Olive M Foster
Arizona State University, Department of Psychology, Tempe, AZ, USA.
Hendrix College, Department of Psychology, Conway, AR, USA.
J Drug Alcohol Res. 2016 May;5. doi: 10.4303/jdar/235967.
In recent years, there has been a dramatic increase in abuse of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV), often in combination with other illicit stimulants.
We sought to determine if repeated exposure to MDPV would produce sensitization to the motor stimulant effects of the drug, and whether cross-sensitization would develop with the stimulant effects of methamphetamine (METH).
Male Sprague-Dawley rats were administered MDPV (1 or 5 mg/kg) or saline once daily for 5 days at 24 hour intervals, or were administered MDPV (1 mg/kg) or saline once daily for 5 days at 48 hour intervals. For cross-sensitization experiments, rats were administered METH (1 mg/kg) or MDPV (1 or 5 mg/kg) once daily for 5 days at 48 hour intervals, and following a 5 day incubation period, were given an acute challenge injection of either MDPV (0.5 mg/kg) or METH (0.5 mg/kg), respectively.
Rats repeatedly administered MDPV (1 mg/kg) every 48 hours, but not every 24 hours, demonstrated increased motor activity when given either a subsequent challenge of MDPV (0.5 mg/kg i.p.) or METH (0.5 mg/kg), indicating the development of behavioral sensitization and cross-sensitization, respectively. Moreover, rats repeatedly administered METH (1 mg/kg) every 48 hours did not exhibit cross-sensitization to the motor stimulating effects of a subsequent challenge with MDPV (0.5 mg/kg).
These results suggest that specific patterns of MDPV administration may lead to lasting changes in behavioral responses to subsequent METH exposure.
近年来，合成卡西酮3,4-亚甲基二氧吡咯戊酮（MDPV）的滥用现象急剧增加，且常与其他非法兴奋剂混合使用。
我们试图确定反复接触MDPV是否会导致对该药物的运动刺激作用产生敏化，以及是否会与甲基苯丙胺（METH）的刺激作用产生交叉敏化。
雄性Sprague-Dawley大鼠以24小时间隔每日一次给予MDPV（1或5毫克/千克）或生理盐水，持续5天；或以48小时间隔每日一次给予MDPV（1毫克/千克）或生理盐水，持续5天。在交叉敏化实验中，大鼠以48小时间隔每日一次给予METH（1毫克/千克）或MDPV（1或5毫克/千克），持续5天，经过5天的潜伏期后，分别给予一次急性激发注射MDPV（0.5毫克/千克）或METH（0.5毫克/千克）。
每48小时而非每24小时反复给予MDPV（1毫克/千克）的大鼠，在随后给予MDPV（0.5毫克/千克腹腔注射）或METH（0.5毫克/千克）激发时，运动活性增加，分别表明出现了行为敏化和交叉敏化。此外，每48小时反复给予METH（1毫克/千克）的大鼠对随后MDPV（0.5毫克/千克）激发的运动刺激作用未表现出交叉敏化。
这些结果表明，特定的MDPV给药模式可能会导致对随后METH暴露的行为反应产生持久变化。
