Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
Trends Mol Med. 2016 Aug;22(8):713-724. doi: 10.1016/j.molmed.2016.05.010. Epub 2016 Jun 7.
Aging is characterized by irreversible loss of physiological integrity, often accompanied by an organism's loss of function and increased vulnerability to death. Defects in the mechanisms preserving cellular homeostasis over time may give rise to accelerated aging. Somatic cell reprogramming of aged cells can be associated with rejuvenation, erasing certain age-associated features, and illustrating the reversibility potential of aging. Here, we focus on recent advances in the generation of human induced pluripotent stem cells from progeroid syndromes and late-onset diseases such as Alzheimer's or Parkinson's. These cellular models have contributed to a better understanding of such pathologies, as well as to the development of novel therapeutic approaches. We also discuss different strategies to identify and target age-associated reprogramming barriers to facilitate the treatment of age-related disorders.
衰老是指生理完整性的不可逆转的丧失，通常伴随着生物体功能的丧失和对死亡的易感性增加。随着时间的推移，维持细胞内稳态的机制缺陷可能导致加速衰老。衰老细胞的体细胞重编程与年轻化有关，可以消除某些与年龄相关的特征，并说明衰老的可逆性潜力。在这里，我们重点介绍了从早衰综合征和阿尔茨海默病或帕金森病等迟发性疾病中生成人类诱导多能干细胞的最新进展。这些细胞模型有助于更好地理解这些病理，以及开发新的治疗方法。我们还讨论了不同的策略来识别和靶向与年龄相关的重编程障碍，以促进与年龄相关的疾病的治疗。
