长时间异氟烷麻醉对犬脑血流量和代谢的影响。
The effects of prolonged isoflurane anaesthesia on cerebral blood flow and metabolism in the dog.
作者信息
Roald O K, Forsman M, Steen P A
机构信息
Department of Anaesthesiology, Aker and Ullevål Hospital, University of Oslo, Norway.
出版信息
Acta Anaesthesiol Scand. 1989 Apr;33(3):210-3. doi: 10.1111/j.1399-6576.1989.tb02892.x.
To determine whether cerebral blood flow (CBF) changed with time under isoflurane anaesthesia, as has been reported for halothane, CBF and cerebral metabolic rate for oxygen (CMRO2) were studied in five dogs under prolonged isoflurane anaesthesia. CBF was measured with a modified sagittal sinus technique and CMRO2 was calculated as the product of CBF and the arteriovenous O2 difference. Maintaining this experimental dog model with 1% isoflurane in oxygen and nitrogen for 3 h in five dogs and for 4 h in three dogs did not cause any significant changes in CMRO2 or CBF. Cerebral metabolite levels were consistent with earlier reports from short-time studies and the EEG recordings showed a continuous sleep pattern with no pathological changes. It is concluded that there is no change in CBF or CMRO2 in our modified sagittal outflow model during 3-4 h of 1% isoflurane anaesthesia.
为了确定脑血流量（CBF）在异氟烷麻醉下是否会像氟烷那样随时间变化，对五只犬在长时间异氟烷麻醉下的脑血流量和脑氧代谢率（CMRO2）进行了研究。采用改良矢状窦技术测量脑血流量，并将脑氧代谢率计算为脑血流量与动静脉氧分压差的乘积。在五只犬中用1%异氟烷加氧气和氮气维持该实验犬模型3小时，在三只犬中维持4小时，未引起脑氧代谢率或脑血流量的任何显著变化。脑代谢物水平与早期短期研究报告一致，脑电图记录显示为持续睡眠模式，无病理变化。结论是，在1%异氟烷麻醉3 - 4小时期间，我们改良的矢状窦流出模型中的脑血流量或脑氧代谢率没有变化。
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