Corvò R, Merlano M, Pallestrini E, Barbieri A, De Lorenzi M, Bacigalupo A, Benasso M, Scarpati D, Toma S
Acta Otorhinolaryngol Ital. 1989 Jan-Feb;9(1):25-32.
From January 1987 to May 1988 sixteen pts with advanced squamous cell carcinoma of the head and neck received a combined treatment based on an alternation of chemotherapy and MFD--radiotherapy. The chemotherapy regimen consisted of CDDP 20 mg/m2 and 5-FU 200 mg/m2 i.v. push, from day 1 to day 5 during weeks 1, 5 and 9. Radiotherapy was administered in two courses of 32 Gy each (total dose 64 Gy), during weeks 2-3 and 6-7. Each course was given in 2 fractions per day, five days per week. All sixteen patients could be evaluated for toxicity and fifteen for response. The following were observed: 7 CR, 6 PR, 1 SD and 1 PD. The overall response rate was 86.6%. Toxicity was high; 43.7% of the patients developed grade III-IV mucositis. These results suggest that CDDP and 5-FU alternating with MFD-radiotherapy is feasible, although new, less toxic scheduling must be determined.
1987年1月至1988年5月，16例晚期头颈部鳞状细胞癌患者接受了基于化疗与MFD-放疗交替的联合治疗。化疗方案为第1、5和9周的第1至5天静脉推注顺铂20mg/m²和氟尿嘧啶200mg/m²。放疗分两个疗程进行，每个疗程32Gy（总剂量64Gy），分别在第2 - 3周和第6 - 7周进行。每个疗程每天分2次给予，每周5天。所有16例患者均可评估毒性，15例可评估疗效。观察到以下结果：7例完全缓解，6例部分缓解，1例疾病稳定，1例疾病进展。总缓解率为86.6%。毒性较高；43.7%的患者出现Ⅲ - Ⅳ级黏膜炎。这些结果表明，顺铂和氟尿嘧啶与MFD-放疗交替使用是可行的，尽管必须确定毒性更小的新方案。
