Martínez-Chapa Arnulfo, Alonso-Reyes Nelly, Luna-Macías Miguel
Ginecol Obstet Mex. 2015 Dec;83(12):770-5.
Historically, cervical cancer in early stages has been treated with radical hysterectomy and radiotherapy with no option in keeping the uterine-ovarian function. Since two decades ago, evidence shows these cases are candidates for radical trachelectomy, a procedure capable of preserving the fertility without affecting the oncological outcome.
To analyze reproductive results among patients treated with radical trachelectomy, in a reference center from the northeast of Mexico.
Between March 1999 and December 2013, 27 cases with cervical cancer in early stages were treated with vaginal or abdominal radical trachelectomy in the ISSSTE Regional Hospital in Monterrey, NL (Mexico). We obtained the gynecological, medical and surgical clinical history. Plan of analysis consisted of descriptive statistics.
Age range was 27-39 years. Main complications were cervical stenosis (n=1) and erosion of cerclaje (n=2). Eighteen patients tried to get pregnant, 8 of them got a spontaneous pregnancy; 1 more patient required assisted reproduction technics and did not succeed. All pregnancies were delivered by cesarean section and were preterm births; 3 underwent premature rupture of membranes. Two pregnancies ended in abortion, one at 10 weeks with severe hemorrhage that needed hysterectomy; the second one, at 1 7 weeks, received a fine uterine curettage. Only 6 cases (33%) got a live birth.
Only one third of the attempted pregnancies got a live birth. Assisted reproduction technics play an important role and should be offer to all cases. Cerclaje is an important factor to carry a pregnancy up to the third trimester.
从历史上看,早期宫颈癌一直采用根治性子宫切除术和放射治疗,无法保留子宫 - 卵巢功能。自二十年前以来,有证据表明这些病例适合进行根治性宫颈切除术,这是一种能够保留生育能力且不影响肿瘤治疗效果的手术。
分析在墨西哥东北部一个参考中心接受根治性宫颈切除术患者的生殖结果。
1999年3月至2013年12月期间,墨西哥新莱昂州蒙特雷市ISSSTE地区医院对27例早期宫颈癌患者进行了阴道或腹部根治性宫颈切除术。我们获取了妇科、内科和外科的临床病史。分析计划包括描述性统计。
年龄范围为27 - 39岁。主要并发症为宫颈狭窄(n = 1)和宫颈环扎侵蚀(n = 2)。18名患者尝试怀孕,其中8名自然受孕;另有1名患者需要辅助生殖技术但未成功。所有妊娠均通过剖宫产分娩,且均为早产;3例发生胎膜早破。2例妊娠以流产告终,1例在10周时因严重出血需要进行子宫切除术;另1例在17周时接受了刮宫术。只有6例(33%)活产。
只有三分之一的尝试妊娠获得活产。辅助生殖技术起着重要作用,应提供给所有病例。宫颈环扎术是维持妊娠至孕晚期的重要因素。