心力衰竭中的可溶性血管内皮生长因子受体-1：与疾病严重程度及生物标志物的关系
Sflt-1 in heart failure: relation with disease severity and biomarkers.
作者信息
Gruson Damien, Hermans Michel P, Ferracin Benjamin, Ahn Sylvie A, Rousseau Michel F
机构信息
a Pôle de Recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium ;
b Department of Laboratory Medicine , Cliniques Universitaires St-Luc and Université Catholique de Louvain , Brussels , Belgium ;
出版信息
Scand J Clin Lab Invest. 2016 Sep;76(5):411-6. doi: 10.1080/00365513.2016.1190863. Epub 2016 Jun 13.
Soluble fms-like tyrosine kinase-1 (sFlt-1) is an endogenous inhibitor of endothelial growth factors, such as placental growth factor (PlGF), which modulates cardiovascular (CV) remodeling. We determine sFlt-1 levels in patients with heart failure (HF) and its relationship to adverse cardiovascular (CV) events and biomarkers of cardiovascular risk. Levels of sFlt-1 and PlGF levels were also determined in healthy volunteers and patients with type 2 diabetes mellitus (T2DM). SFlt-1 and PlGF were clearly increased in HF patients in comparison to T2DM patients or healthy subjects (p < 0.01). Concentration of sFlt-1 was related to HF severity (p < 0.001) and was correlated to NT-proBNP (ρ = 0.37, p < 0.01), soluble ST2 (ρ = 0.52, p < 0.01), Galectin-3 (ρ = 0.38, p < 0.01), aldosterone (ρ = 0.25, p = 0.01) and PTH(1-84) (ρ = 0.38, p < 0.01). Furthermore, sFlt-1 levels were associated to long-term CV risk. These results suggest a potential role of sFlt-1 in HF and its potential role as biomarker of CV risk.
可溶性fms样酪氨酸激酶-1（sFlt-1）是内皮生长因子的内源性抑制剂，如胎盘生长因子（PlGF），其可调节心血管（CV）重塑。我们测定了心力衰竭（HF）患者的sFlt-1水平及其与不良心血管（CV）事件和心血管风险生物标志物的关系。还测定了健康志愿者和2型糖尿病（T2DM）患者的sFlt-1水平和PlGF水平。与T2DM患者或健康受试者相比，HF患者的sFlt-1和PlGF水平明显升高（p<0.01）。sFlt-1浓度与HF严重程度相关（p<0.001），并与NT-proBNP（ρ=0.37，p<0.01）、可溶性ST2（ρ=0.52，p<0.01）、半乳糖凝集素-3（ρ=0.38，p<0.01）、醛固酮（ρ=0.25，p=0.01）和甲状旁腺激素（1-84）（ρ=0.38，p<0.01）相关。此外，sFlt-1水平与长期CV风险相关。这些结果提示sFlt-1在HF中的潜在作用及其作为CV风险生物标志物的潜在作用。
Zotero 插件