Department of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9, Łódź, Poland.
Curr Hypertens Rep. 2018 Jul 3;20(8):71. doi: 10.1007/s11906-018-0869-8.
Preeclampsia (PE) is a hypertensive disorder exclusive for pregnancy. It affects women all over the world and poses a great threat to life, both for mother and child. No definitive treatment exists and placenta delivery comprises the only known cure for PE. One of the most severe complications observed in preeclamptic women is the occurrence of cardiovascular diseases (CVDs) later in life.
Both PE and CVDs share some of their pathogenic pathways and gene variations. Thus far, a number of publications have examined those relationships; however, almost all of them focus only on common risk factors. The precise pathomechanism and genetic basis of PE and its associated cardiovascular complications remain unknown. Therefore, the aim of this review is to unify and clarify the current state of knowledge and provide direction for future studies, especially those regarding the genetic aspect.
子痫前期（PE）是一种仅发生于妊娠的高血压疾病。它影响着全世界的女性，对母婴的生命都构成了巨大威胁。目前尚无明确的治疗方法，胎盘娩出是子痫前期唯一已知的治愈方法。在子痫前期女性中观察到的最严重的并发症之一是日后发生心血管疾病（CVDs）。
PE 和 CVDs 有一些共同的发病途径和基因变异。到目前为止，已有许多出版物研究了这些关系；然而，几乎所有这些研究都只关注常见的危险因素。PE 及其相关心血管并发症的确切发病机制和遗传基础尚不清楚。因此，本综述的目的是统一和澄清目前的知识状况，并为未来的研究提供方向，特别是那些关于遗传方面的研究。
