Matravers J, Tyldesley W R
Br J Oral Surg. 1978 Mar;15(3):203-14. doi: 10.1016/0007-117x(78)90002-1.
The technique described in Part I, has been extended to the examination of cells removed by scraping from 22 lesions of oral lichen planus and leukoplakia. It was concluded that the surface morphology of the cells from these lesions was intermediate between that of normal tissue and of malignant tissue. The observations have been quantified and subjected to computer analysis together with the data derived from the observations of normal and malignant tissue. This confirms the visual observation that a relationship exists between the modified surface characteristics of the cells from these lesions and their subjectively assessed histological appearances. A correlation has been found between the SEM appearance and an epithelial atypia index (EAI) derived according to the criteria of Smith and Pindborg (1969). In the case of lichen planus inflammatory changes appear to be associated with increased modification of surface characteristics. These changes are also reflected in an increased EAI. It is suggested that the present technique may be of value in the diagnosis and assessment of potentially malignant lesions.
第一部分所描述的技术已扩展到对从22例口腔扁平苔藓和白斑病变刮除的细胞进行检查。得出的结论是，这些病变细胞的表面形态介于正常组织和恶性组织之间。这些观察结果已被量化，并与来自正常组织和恶性组织观察的数据一起进行计算机分析。这证实了视觉观察结果，即这些病变细胞改变的表面特征与其主观评估的组织学外观之间存在关联。已发现扫描电镜外观与根据史密斯和平德伯格（1969年）标准得出的上皮异型性指数（EAI）之间存在相关性。在扁平苔藓的情况下，炎症变化似乎与表面特征的改变增加有关。这些变化也反映在EAI的增加上。有人认为，目前的技术可能在潜在恶性病变的诊断和评估中具有价值。
