Hurrell R F, Furniss D E, Burri J, Whittaker P, Lynch S R, Cook J D
Nestlé Research Center, Nestec Ltd, Vers-chez-les-Blanc, Lausanne, Switzerland.
Am J Clin Nutr. 1989 Jun;49(6):1274-82. doi: 10.1093/ajcn/49.6.1274.
Hemoglobin-repletion tests in rats, organoleptic studies, and iron-absorption studies in humans were used to search for Fe sources with high bioavailability that could be added to infant cereals as alternatives to the Fe compounds currently used for fortification. From rat and organoleptic studies on 11 alternative Fe sources, ferrous fumarate, ferrous succinate, and ferric saccharate were selected as the most suitable for infant-cereal fortification and, by use of radioactive labels, absorption of those compounds from fortified cereal was measured in adult human volunteers. There was no difference in absorption between ferrous fumarate and ferrous sulfate whereas the values for ferrous succinate, ferrous saccharate (10% Fe), and ferric pyrophosphate were 92%, 74%, and 39% of the ferrous sulfate values, respectively. We conclude that ferrous fumarate and ferrous succinate are highly available Fe sources in man that can be used to fortify infant cereals without causing fat oxidation or discoloration.
通过对大鼠进行血红蛋白补充试验、开展感官研究以及对人体进行铁吸收研究，来寻找生物利用率高的铁源，以便将其添加到婴儿谷物食品中，作为当前用于强化的铁化合物的替代品。通过对11种替代铁源进行大鼠和感官研究，富马酸亚铁、琥珀酸亚铁和蔗糖铁被选为最适合婴儿谷物强化的铁源，并利用放射性标记物，在成年人类志愿者中测量了这些化合物从强化谷物中的吸收情况。富马酸亚铁和硫酸亚铁的吸收没有差异，而琥珀酸亚铁、蔗糖铁（10%铁）和焦磷酸铁的吸收值分别为硫酸亚铁吸收值的92%、74%和39%。我们得出结论，富马酸亚铁和琥珀酸亚铁在人体中是生物利用率高的铁源，可用于强化婴儿谷物食品而不会导致脂肪氧化或变色。
