Fidler Meredith C, Walczyk Thomas, Davidsson Lena, Zeder Christophe, Sakaguchi Noboru, Juneja Lekh R, Hurrell Richard F
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology (ETH) Zurich, PO Box 474/Seestrasse 72, CH-8803 Rüschlikon, Switzerland.
Br J Nutr. 2004 Jan;91(1):107-12. doi: 10.1079/bjn20041018.
Ferric pyrophosphate is a water-insoluble Fe compound used to fortify infant cereals and chocolate-drink powders as it causes no organoleptic changes to the food vehicle. However, it is only of low absorption in man. Recently, an innovative ferric pyrophosphate has been developed (Sunactive Fe trade mark ) based on small-particle-size ferric pyrophosphate (average size 0.3 microm) mixed with emulsifiers, so that it remains in suspension in liquid products. The aim of the present studies was to compare Fe absorption of micronised, dispersible ferric pyrophosphate (Sunactive Fe trade mark ) with that of ferrous sulfate in an infant cereal and a yoghurt drink. Two separate Fe absorption studies were made in adult women (ten women/study). Fe absorption was based on the erythrocyte incorporation of stable isotopes ((57)Fe and (58)Fe) 14 d after the intake of labelled test meals of infant cereal (study 1) or yoghurt drink (study 2). Each test meal was fortified with 5 mg Fe as ferrous sulfate or micronised, dispersible ferric pyrophosphate. Results are presented as geometric means. There was no statistically significant difference between Fe absorption from micronised, dispersible ferric pyrophosphate- and ferrous sulfate-fortified infant cereal (3.4 and 4.1 % respectively; P=0.24) and yoghurt drink (3.9 and 4.2 % respectively; P=0.72). The results of the present studies show that micronised, dispersible ferric pyrophosphate is as well absorbed as ferrous sulfate in adults. The high relative Fe bioavailability of micronised, dispersible ferric pyrophosphate indicates the potential usefulness of this compound for food fortification.
焦磷酸铁是一种水不溶性铁化合物，用于强化婴儿谷物食品和巧克力饮料粉，因为它不会引起食品载体的感官变化。然而，它在人体中的吸收率较低。最近，一种创新的焦磷酸铁（Sunactive Fe商标）已被开发出来，它是基于小粒径的焦磷酸铁（平均粒径0.3微米）与乳化剂混合而成，这样它就能在液体产品中保持悬浮状态。本研究的目的是比较微粉化、可分散的焦磷酸铁（Sunactive Fe商标）与硫酸亚铁在婴儿谷物食品和酸奶饮料中的铁吸收率。在成年女性中进行了两项独立的铁吸收研究（每项研究10名女性）。铁吸收是基于摄入婴儿谷物食品（研究1）或酸奶饮料（研究2）的标记测试餐后14天红细胞对稳定同位素（57Fe和58Fe）的掺入情况。每餐用5毫克铁作为硫酸亚铁或微粉化、可分散的焦磷酸铁进行强化。结果以几何平均数表示。微粉化、可分散的焦磷酸铁强化的婴儿谷物食品和硫酸亚铁强化的婴儿谷物食品之间的铁吸收率（分别为3.4%和4.1%；P = 0.24）以及微粉化、可分散的焦磷酸铁强化的酸奶饮料和硫酸亚铁强化的酸奶饮料之间的铁吸收率（分别为3.9%和4.2%；P = 0.72）没有统计学上的显著差异。本研究结果表明，微粉化、可分散的焦磷酸铁在成年人中的吸收情况与硫酸亚铁一样好。微粉化、可分散的焦磷酸铁的高相对铁生物利用率表明该化合物在食品强化方面具有潜在的用途。
