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特应性皮炎：临床内涵，尤其关注免疫受损/易感性遗传和代谢紊乱中伴发的特应性底色。

Atopic Dermatitis: Clinical Connotations, Especially a Focus on Concomitant Atopic Undertones in Immunocompromised/Susceptible Genetic and Metabolic Disorders.

作者信息

Sehgal Virendra N, Khurana Ananta, Mendiratta Vibhu, Saxena Deepti, Srivastava Govind, Aggarwal Ashok K, Chatterjee Kingshuk

机构信息

Dermato Venereology (Skin/VD) Center, Sehgal Nursing Home, New Delhi, India.

Department of Dermatology, Dr. RML Hospital, Postgraduate Institute of Medical Education and Research, New Delhi, India.

出版信息

Indian J Dermatol. 2016 May-Jun;61(3):241-50. doi: 10.4103/0019-5154.182433.

DOI:10.4103/0019-5154.182433
PMID:27293243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4885175/
Abstract

Atopic dermatitis (AD) is an intriguing clinical entity. Its clinical connotations are varied, the updates of which are required to be done periodically. An attempt to bring its various facets have been made highlighting its clinical features keeping in view the major and the minor criteria to facilitate the diagnosis, differential diagnosis, complications, and associated dermatoses. The benefit of the current dissertation may percolate to the trainees in dermatology, in addition to revelations that atopic undertones in genetic susceptibility and metabolic disorder may provide substantive insight for the future in the understanding of thus far enigmatic etiopathogenesis of AD.

摘要

特应性皮炎（AD）是一种引人关注的临床病症。其临床内涵多样，需要定期进行更新。本文试图从多方面阐述其临床特征，同时兼顾主要和次要标准，以利于诊断、鉴别诊断、并发症及相关皮肤病的判断。本论文的成果不仅可能惠及皮肤科 trainees，还揭示了遗传易感性和代谢紊乱中的特应性因素，有望为今后深入理解AD至今仍扑朔迷离的病因发病机制提供重要线索。 （注：“trainees”直接保留英文未翻译，因为不清楚具体所指对象，在医学领域可能有特定含义不便随意翻译，比如实习医生、进修人员等，需结合上下文确定准确中文表述。）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/bcf63970ea30/IJD-61-241-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/79de03b67f0c/IJD-61-241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/ebb79b6c6713/IJD-61-241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/adb3c5beea0b/IJD-61-241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/210c72b6c9a6/IJD-61-241-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/888da183c69d/IJD-61-241-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/51ab7f2e0e4e/IJD-61-241-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/bcf63970ea30/IJD-61-241-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/79de03b67f0c/IJD-61-241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/ebb79b6c6713/IJD-61-241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/adb3c5beea0b/IJD-61-241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/210c72b6c9a6/IJD-61-241-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/888da183c69d/IJD-61-241-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/51ab7f2e0e4e/IJD-61-241-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2322/4885175/bcf63970ea30/IJD-61-241-g008.jpg

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本文引用的文献

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2
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Indian J Dermatol. 2015 Jul-Aug;60(4):327-31. doi: 10.4103/0019-5154.160474.
3
Atopic diathesis in hypohidrotic/anhidrotic ectodermal dysplasia.低汗型/无汗型外胚层发育不良中的特应性素质。
Acta Derm Venereol. 2015 Apr;95(4):476-9. doi: 10.2340/00015555-1978.
4
IgE allergen component-based profiling and atopic manifestations in patients with Netherton syndrome.Netherton综合征患者基于IgE变应原成分的分析及特应性表现
J Allergy Clin Immunol. 2014 Oct;134(4):985-8. doi: 10.1016/j.jaci.2014.07.008. Epub 2014 Aug 23.
5
Increased risk of idiopathic nephrotic syndrome in children with atopic dermatitis.患有特应性皮炎的儿童患特发性肾病综合征的风险增加。
Pediatr Nephrol. 2014 Nov;29(11):2157-63. doi: 10.1007/s00467-014-2835-2. Epub 2014 Jul 18.
6
The histamine-synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin.组氨酸脱羧酶是一种合成组胺的酶，在特应性皮炎皮肤中由角质形成细胞上调。
Br J Dermatol. 2014 Oct;171(4):771-8. doi: 10.1111/bjd.13199. Epub 2014 Sep 30.
7
Celiac disease in children with atopic dermatitis.患有特应性皮炎的儿童的乳糜泻
Pediatr Dermatol. 2014 Jul-Aug;31(4):483-8. doi: 10.1111/pde.12372. Epub 2014 May 16.
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Atopic dermatitis, short stature, skeletal malformations, hyperimmunoglobulin E syndrome, hypereosinophilia and recurrent infections: a case report.特应性皮炎、身材矮小、骨骼畸形、高免疫球蛋白E综合征、嗜酸性粒细胞增多症及反复感染：一例报告
J Med Case Rep. 2013 Nov 7;7:253. doi: 10.1186/1752-1947-7-253.
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