Abed Firas, Baniya Ramkaji, Bachuwa Ghassan
Hurley Medical Center, College of Human Medicine, Michigan State University, Flint, MI, USA; Henry Ford Hospital, Detroit, MI, USA.
Hurley Medical Center, College of Human Medicine, Michigan State University, Flint, MI, USA.
Case Rep Med. 2016;2016:9136825. doi: 10.1155/2016/9136825. Epub 2016 May 16.
Every drug comes with some side effect. It is the benefit/risk ratio that determines the medical use of the drug. Quinine, a known antimalarial drug, has been used for nocturnal leg cramps since the 1930s; it is associated with severe life-threatening hematological and cardiovascular side effects. Disseminated intravascular coagulation (DIC), albeit rare, is a known coagulopathy associated with Quinine. It is imperative to inquire about the Quinine intake in medication history in patients with coagulopathy, as most patients still consider it a harmless home remedy for nocturnal leg cramps. In this report, we present a case of coagulopathy in a middle-aged woman, who gave a history of taking Quinine for nocturnal leg cramps, as her home remedy. Early identification of the offending agent led to the diagnosis, prompt discontinuation of the medication, and complete recovery and prevented the future possibility of recurrence.
每种药物都有一些副作用。决定药物医学用途的是效益/风险比。奎宁是一种已知的抗疟药物，自20世纪30年代以来一直用于治疗夜间腿部痉挛；它与严重的、危及生命的血液学和心血管副作用有关。弥散性血管内凝血（DIC）虽然罕见，但却是一种已知的与奎宁相关的凝血病。对于患有凝血病的患者，询问其用药史中是否服用过奎宁至关重要，因为大多数患者仍将其视为治疗夜间腿部痉挛的无害家庭疗法。在本报告中，我们介绍了一名中年女性凝血病病例，她有服用奎宁治疗夜间腿部痉挛的病史，将其作为家庭疗法。早期识别致病因素导致了诊断、及时停药、完全康复，并防止了未来复发的可能性。
