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肾血栓性微血管病与FIP1L1/PDGFRα相关的嗜酸性粒细胞增多综合征的骨髓增殖性变异型

Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome.

作者信息

Langlois Anne Lyse, Shehwaro Nathalie, Rondet Claire, Benbrik Youssef, Maloum Karim, Gueutin Victor, Rouvier Philippe, Izzedine Hassane

机构信息

Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.

Department of Internal Medicine, School of Medicine, Department of General Practice , Saint Antoine Hospital, UPMC University Paris 06 , Paris , France.

出版信息

Clin Kidney J. 2013 Aug;6(4):418-20. doi: 10.1093/ckj/sft067.

DOI:10.1093/ckj/sft067
PMID:27293571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4898340/
Abstract

We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of thrombosis is at least in part related to damage from activated eosinophils.

摘要

我们报告了一例24岁男性的高嗜酸性粒细胞综合征（HES）骨髓增殖性变异型中的肾血栓性微血管病（TMA），该病例经伊马替尼治疗后痊愈。这是迄今为止文献中少数描述HES中TMA的病例之一，提示血栓形成的发病机制至少部分与活化嗜酸性粒细胞造成的损伤有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/4898340/2e79b11496a5/sft06701.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/4898340/2e79b11496a5/sft06701.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34f/4898340/2e79b11496a5/sft06701.jpg

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本文引用的文献

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Renal involvement as the first manifestation of hypereosinophilic syndrome: a case report.以肾脏受累为首发表现的高嗜酸性粒细胞综合征1例报告
NDT Plus. 2009 Oct;2(5):379-81. doi: 10.1093/ndtplus/sfp092. Epub 2009 Aug 1.
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Renal infarction in hypereosinophilic syndrome.高嗜酸性粒细胞综合征中的肾梗死
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Refining the definition of hypereosinophilic syndrome.细化嗜酸性粒细胞增多综合征的定义。
Eosinophilia and Kidney Disease: More than Just an Incidental Finding?
嗜酸性粒细胞增多与肾脏疾病：仅仅是偶然发现吗？
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Evaluation of cardiac involvement in hypereosinophilic syndrome: complementary roles of transthoracic, transesophageal, and contrast echocardiography.高嗜酸性粒细胞综合征中心脏受累情况的评估：经胸、经食管及造影超声心动图的互补作用
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Thrombotic microangiopathy associated with the hypereosinophilic syndrome.与高嗜酸性粒细胞综合征相关的血栓性微血管病。
Kidney Int. 2005 May;67(5):1806-11. doi: 10.1111/j.1523-1755.2005.00278.x.
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Recent advances in pathogenesis and management of hypereosinophilic syndromes.高嗜酸性粒细胞综合征的发病机制与治疗新进展
Allergy. 2004 Jul;59(7):673-89. doi: 10.1111/j.1398-9995.2004.00465.x.
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Immunotactoid glomerulopathy associated with idiopathic hypereosinophilic syndrome.与特发性嗜酸性粒细胞增多综合征相关的免疫触须样肾小球病。
Am J Nephrol. 1998;18(4):337-43. doi: 10.1159/000013362.
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MPO-ANCA-positive crescentic necrotizing glomerulonephritis and tubulointerstitial nephritis with renal eosinophilic infiltration and peripheral blood eosinophilia.髓过氧化物酶抗中性粒细胞胞浆抗体（MPO-ANCA）阳性的新月体性坏死性肾小球肾炎及肾小管间质性肾炎，伴有肾脏嗜酸性粒细胞浸润及外周血嗜酸性粒细胞增多。
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Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease.嗜酸性粒细胞阳离子颗粒蛋白损害血栓调节蛋白功能。嗜酸性粒细胞增多性心脏病中血栓栓塞的一种潜在机制。
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