肾血栓性微血管病与FIP1L1/PDGFRα相关的嗜酸性粒细胞增多综合征的骨髓增殖性变异型
Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome.
作者信息
Langlois Anne Lyse, Shehwaro Nathalie, Rondet Claire, Benbrik Youssef, Maloum Karim, Gueutin Victor, Rouvier Philippe, Izzedine Hassane
机构信息
Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
Department of Internal Medicine, School of Medicine, Department of General Practice , Saint Antoine Hospital, UPMC University Paris 06 , Paris , France.
出版信息
Clin Kidney J. 2013 Aug;6(4):418-20. doi: 10.1093/ckj/sft067.
We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of thrombosis is at least in part related to damage from activated eosinophils.
我们报告了一例24岁男性的高嗜酸性粒细胞综合征（HES）骨髓增殖性变异型中的肾血栓性微血管病（TMA），该病例经伊马替尼治疗后痊愈。这是迄今为止文献中少数描述HES中TMA的病例之一，提示血栓形成的发病机制至少部分与活化嗜酸性粒细胞造成的损伤有关。
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