二甲基乙酰胺所致职业性中毒性肝病伴短期复发：1例罕见病例报告
Dimethylacetamide-induced occupational toxic hepatitis with a short term recurrence: a rare case report.
作者信息
Gong Wei, Liu Xin, Zhu Baoli
机构信息
Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China.
出版信息
J Thorac Dis. 2016 Jun;8(6):E408-11. doi: 10.21037/jtd.2016.04.44.
Abstract
In recent years, N,N-dimethylacetamide (DMAc) is widely used in the textile and plastics industry as a solvent alternative to more toxic N,N-dimethylformamide (DMF). At home and abroad, sporadic group case reports have revealed that DMAc could cause toxic hepatitis and symptoms or signs indicative of liver involvement among workers exposed to DMAc, with severe cases leading to death. This paper reports a rare case of severe acute toxic hepatitis with a short term recurrence induced by occupational contact with DMAc in a polyimide film factory, as well as in-depth analysis via relevant information and literature.
摘要
近年来，N，N-二甲基乙酰胺（DMAc）作为毒性更强的N，N-二甲基甲酰胺（DMF）的替代溶剂，在纺织和塑料行业中被广泛使用。在国内外，零星的群体病例报告显示，DMAc可导致接触DMAc的工人出现中毒性肝炎以及肝脏受累的症状或体征，严重病例可导致死亡。本文报告了一例在聚酰亚胺薄膜厂因职业接触DMAc引发的短期复发的严重急性中毒性肝炎罕见病例，并通过相关资料及文献进行深入分析。
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