Cervellin Gianfranco, Mattiuzzi Camilla, Bovo Chiara, Lippi Giuseppe
1 Emergency Department, Academic Hospital of Parma, Parma, Italy ; 2 Medical Direction, General Hospital of Trento, Trento, Italy ; 3 Medical Direction, University Hospital of Verona, Verona, Italy ; 4 Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Ann Transl Med. 2016 May;4(10):193. doi: 10.21037/atm.2016.05.16.
The rather short history of diagnostic algorithms for investigating patients with a suspected acute coronary syndrome (ACS) has led to a constantly evolving and unquestionably chaotic scenario. Although the recent development and introduction of high-sensitivity immunoassays for the measurement of cardiac troponins has represented a paradigm shift for dispersing part of the overwhelming fog, many uncertainties remain, especially concerning the appropriate timing for serial testing and the interpretation of cardiac troponin variations over time. Therefore, the aim of this article is to review the available evidence about diagnostic algorithms for ACS which incorporate the measurement of cardiac troponins, and generate a final algorithm attempting to integrate and harmonize the many clinical and laboratory findings emerged from the recent scientific literature.
用于诊断疑似急性冠状动脉综合征（ACS）患者的算法历史相对较短，这导致了一种不断演变且无疑混乱的局面。尽管最近开发并引入了用于测量心肌肌钙蛋白的高灵敏度免疫测定法，这在驱散部分迷雾方面代表了一种范式转变，但仍存在许多不确定性，尤其是关于连续检测的合适时机以及心肌肌钙蛋白随时间变化的解读。因此，本文的目的是回顾关于纳入心肌肌钙蛋白测量的ACS诊断算法的现有证据，并生成一种最终算法，试图整合和协调近期科学文献中出现的众多临床和实验室研究结果。
