Geduspan J S, MacCabe J A
Department of Zoology, University of Tennessee, Knoxville 37996.
Anat Rec. 1989 May;224(1):79-87. doi: 10.1002/ar.1092240110.
Control of dorsoventral patterns in the chick at the prelimb stages resides in the limb mesoderm. Recombination experiments at stage 14, with dorsoventrally reversed ectoderm, result in wings with mesodermal dorsoventral polarity. Similar recombinations at stage 16 show that the ectoderm has acquired dorsoventral information and can impose this polarity on the patterns of mesodermal differentiation in the distal regions of the wing. The dorsoventral information in the ectoderm comes from the mesoderm, which transfers this information to the overlying ectoderm between stages 14 and 16. The initial dorsoventral overlying ectoderm between stages 14 and 16. The initial dorsoventral information in the ectoderm is not stable and can be reprogrammed by stage 14 mesoderm. Subsequently, there is a gradual stabilization of the ectodermal information. At the same time the mesoderm loses its capacity to reprogram dorsoventral information in the ectoderm.
鸡胚前肢阶段背腹模式的控制位于肢体中胚层。在第14阶段进行的重组实验中，将背腹颠倒的外胚层进行重组，结果产生了具有中胚层背腹极性的翅膀。在第16阶段进行类似的重组表明，外胚层已经获得了背腹信息，并能将这种极性施加于翅膀远端区域中胚层分化的模式上。外胚层中的背腹信息来自中胚层，中胚层在第14至第16阶段之间将此信息传递给覆盖其上的外胚层。外胚层中最初的背腹信息不稳定，在第14阶段可被中胚层重新编程。随后，外胚层信息逐渐稳定。与此同时，中胚层失去了对外胚层背腹信息进行重新编程的能力。
