Lee Jun Ho, Kim Dong-Kyu, Park Hae Sang, Jeong Ju Yeon, Yeon Yeung Kyu, Kumar Vijay, Bae Sung Hee, Lee Jung Min, Moon Bo Mi, Park Chan Hum
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.
Nano-Bio Regenerative Medical Institute, Hallym University, Gangwon, South Korea.
Laryngoscope. 2016 Dec;126(12):2798-2803. doi: 10.1002/lary.25980. Epub 2016 Jun 13.
OBJECTIVES/HYPOTHESIS: Silk fibroin patching has been used to repair acute tympanic membrane perforations. Here, we describe the advantages and outcomes of this technique for chronic tympanic membrane perforations.
Individual cohort study.
Forty patients were enrolled; half underwent perichondrium myringoplasty, and the silk fibroin patch technique was applied in the remaining patients. We compared the closure, otorrhea, and complication rates; closure time; postoperative hearing gain; and patient satisfaction between the two groups.
Demographic data (gender, site, age, duration, preoperative air-bone gap, and perforation size and location) were not significantly different between the two groups. The closure rates and times, complication rates, and postoperative hearing gains were also similar in both groups. The mean operative time, otorrhea rate, and complication rate were also significantly better in the silk fibroin patch group. The intraoperative dizziness scores were higher in the conventional perichondrium myringoplasty group.
Success rates were similar for the silk fibroin patch technique and conventional perichondrium myringoplasty; however, patching was an easier, faster procedure. Our results suggest that the silk fibroin patch technique is a suitable treatment for chronic tympanic membrane perforation.
2b Laryngoscope, 126:2798-2803, 2016.
目的/假设：丝素蛋白修补术已被用于修复急性鼓膜穿孔。在此，我们描述该技术用于慢性鼓膜穿孔的优势和效果。
个体队列研究。
纳入40例患者；其中一半接受软骨膜鼓膜成形术，其余患者应用丝素蛋白修补技术。我们比较了两组的愈合率、耳漏和并发症发生率、愈合时间、术后听力改善情况以及患者满意度。
两组的人口统计学数据（性别、部位、年龄、病程、术前气骨导差、穿孔大小和位置）无显著差异。两组的愈合率和时间、并发症发生率以及术后听力改善情况也相似。丝素蛋白修补组的平均手术时间、耳漏率和并发症发生率也明显更好。传统软骨膜鼓膜成形术组的术中眩晕评分更高。
丝素蛋白修补技术和传统软骨膜鼓膜成形术的成功率相似；然而，修补术是一种更简便、更快的手术。我们的结果表明，丝素蛋白修补技术是治疗慢性鼓膜穿孔的一种合适方法。
2b 《喉镜》，2016年，第126卷，第2798 - 2803页
