Elia F, Paolino G, Donati M, Solivetti F M
Department of Radiology, San Gallicano Dermatologic Institute for Research and Care, Via Elio Chianesi 53, 00144 Rome, Italy.
Department of Dermopathology, San Gallicano Dermatologic Institute for Research and Care, Rome, Italy.
J Ultrasound. 2015 Oct 16;19(2):145-7. doi: 10.1007/s40477-015-0184-z. eCollection 2016.
Multiple miliaryosteoma cutis (MMOC) is a rare nodular skin disease, characterized by tiny bone nodules in the dermis and subcutaneous tissue, presenting clinically as multiple normochromic papules and nodules, usually on the face. We described the case of MMOC of the face in a woman, ultrasonically evaluated with very high frequency probe.
A 45-year-old patient with multiple papules, 3-5 mm in diameter, grouped in the frontal region. Skin ultrasound examination, cutaneous biopsy and laboratory evaluation were performed.
High-frequency ultrasound showed the presence of multiple hyperechogenic linear and roundish structures, associated by hypoechogenic shadow. The histology revealed a normal orthokeratotic stratified epithelium with fragment of mature lamellar bone localized at level of the reticular dermis. Laboratory evaluation was normal. According to the clinical, pathological, laboratory and instrumental analyses, a final diagnosis of miliaryosteoma cutis (or primary osteoma cutis not associated with Albright's hereditary osteodystrophy) was made.
In case of multiple papules of subcutaneous tissue, the diagnosis of MMOC, although rare, should be considered and high-frequency sonography, identifying the calcifications, suggests diagnosis.
多发性皮肤粟丘疹（MMOC）是一种罕见的结节性皮肤病，其特征为真皮和皮下组织内出现微小骨结节，临床上表现为多发性正常色素沉着丘疹和结节，通常位于面部。我们描述了一名女性面部MMOC病例，并使用高频探头进行了超声评估。
一名45岁患者，前额区域有多个直径3 - 5毫米的丘疹。进行了皮肤超声检查、皮肤活检和实验室评估。
高频超声显示存在多个高回声线性和圆形结构，并伴有低回声阴影。组织学检查显示为正常的正角化分层上皮，成熟板层骨碎片位于网状真皮层。实验室评估正常。根据临床、病理、实验室和仪器分析，最终诊断为皮肤粟丘疹（或与奥尔布赖特遗传性骨营养不良无关的原发性皮肤骨瘤）。
对于皮下组织出现多个丘疹的情况，尽管MMOC罕见，但应考虑其诊断，高频超声可识别钙化，有助于诊断。
