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本文引用的文献

1
Chronic staphylococcal osteomyelitis: treatment with regimens containing rifampin.慢性葡萄球菌骨髓炎：含利福平方案的治疗
Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S495-501. doi: 10.1093/clinids/5.supplement_3.s495.
2
Rifampin drug interactions.利福平的药物相互作用。
Arch Intern Med. 1984 Aug;144(8):1667-71. doi: 10.1001/archinte.144.8.1667.
3
The antimicrobial activity of rifampin: emphasis on the relation to phagocytes.利福平的抗菌活性：着重于与吞噬细胞的关系。
Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S463-7. doi: 10.1093/clinids/5.supplement_3.s463.
4
Pharmacokinetics and metabolism of rifampin in humans.利福平在人体内的药代动力学与代谢
Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S428-32. doi: 10.1093/clinids/5.supplement_3.s428.
5
The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs.环丙沙星对军团菌属的抗菌活性及豚鼠实验性军团菌肺炎的治疗
J Antimicrob Chemother. 1986 Aug;18(2):251-60. doi: 10.1093/jac/18.2.251.
6
Altered pharmacokinetic disposition of ciprofloxacin and vancomycin after single and multiple doses in rabbits.单次及多次给药后家兔体内环丙沙星和万古霉素药代动力学特征的改变
Antimicrob Agents Chemother. 1987 Jul;31(7):1075-8. doi: 10.1128/AAC.31.7.1075.
7
Treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis with ciprofloxacin or vancomycin alone or in combination with rifampin.单用环丙沙星或万古霉素，或联合利福平治疗耐甲氧西林金黄色葡萄球菌实验性骨髓炎。
Am J Med. 1987 Apr 27;82(4A):73-5.
8
Tissue penetration and metabolism of ciprofloxacin.环丙沙星的组织穿透性与代谢
Am J Med. 1987 Apr 27;82(4A):103-7.
9
Mycobacterium avium complex infection.鸟分枝杆菌复合群感染
J Infect Dis. 1988 May;157(5):863-7. doi: 10.1093/infdis/157.5.863.
10
Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model.抗菌药物药代动力学参数与动物模型治疗效果的相关性。
J Infect Dis. 1988 Oct;158(4):831-47. doi: 10.1093/infdis/158.4.831.

多次给兔子服用利福平后环丙沙星的消除增强。

Enhanced elimination of ciprofloxacin after multiple-dose administration of rifampin to rabbits.

作者信息

Barriere S L, Kaatz G W, Seo S M

机构信息

Department of Pharmaceutical Services, UCLA Center for the Health Sciences 90024.

出版信息

Antimicrob Agents Chemother. 1989 Apr;33(4):589-90. doi: 10.1128/AAC.33.4.589.

DOI:10.1128/AAC.33.4.589
PMID:2729952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172487/
Abstract

The combination of ciprofloxacin and rifampin is potentially useful for the treatment of selected infections. However, rifampin may induce the metabolism of ciprofloxacin. Ciprofloxacin was given in single doses to healthy rabbits before and after six daily doses of intramuscular rifampin. Total clearance of ciprofloxacin increased from 0.96 +/- 0.32 (standard deviation) to 1.57 +/- 0.63 liters/h per kg (P less than 0.05). This change in elimination is potentially significant for the outcome of experimental infections in rabbits.

摘要

环丙沙星和利福平联合使用可能对某些特定感染的治疗有效。然而，利福平可能会诱导环丙沙星的代谢。在给健康兔子每日肌肉注射利福平六次之前和之后，分别给兔子单剂量注射环丙沙星。环丙沙星的总清除率从0.96±0.32（标准差）升/小时·千克增加到1.57±0.63升/小时·千克（P<0.05）。这种消除变化对于兔子实验性感染的结果可能具有重要意义。