多次给兔子服用利福平后环丙沙星的消除增强。
Enhanced elimination of ciprofloxacin after multiple-dose administration of rifampin to rabbits.
作者信息
Barriere S L, Kaatz G W, Seo S M
机构信息
Department of Pharmaceutical Services, UCLA Center for the Health Sciences 90024.
出版信息
Antimicrob Agents Chemother. 1989 Apr;33(4):589-90. doi: 10.1128/AAC.33.4.589.
Abstract
The combination of ciprofloxacin and rifampin is potentially useful for the treatment of selected infections. However, rifampin may induce the metabolism of ciprofloxacin. Ciprofloxacin was given in single doses to healthy rabbits before and after six daily doses of intramuscular rifampin. Total clearance of ciprofloxacin increased from 0.96 +/- 0.32 (standard deviation) to 1.57 +/- 0.63 liters/h per kg (P less than 0.05). This change in elimination is potentially significant for the outcome of experimental infections in rabbits.
摘要
环丙沙星和利福平联合使用可能对某些特定感染的治疗有效。然而，利福平可能会诱导环丙沙星的代谢。在给健康兔子每日肌肉注射利福平六次之前和之后，分别给兔子单剂量注射环丙沙星。环丙沙星的总清除率从0.96±0.32（标准差）升/小时·千克增加到1.57±0.63升/小时·千克（P<0.05）。这种消除变化对于兔子实验性感染的结果可能具有重要意义。
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