1型糖尿病的环境风险因素。
Environmental risk factors for type 1 diabetes.
作者信息
Rewers Marian, Ludvigsson Johnny
机构信息
Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.
Division of Pediatrics, Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University and Linköping University Hospital, Linköping, Sweden.
出版信息
Lancet. 2016 Jun 4;387(10035):2340-2348. doi: 10.1016/S0140-6736(16)30507-4.
Abstract
The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to β cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.
摘要
在过去30年里，由于环境变化（但仅部分被识别），1型糖尿病的发病率显著上升。在本系列论文中，我们批判性地讨论了胰岛自身免疫的候选触发因素以及被认为促进从自身免疫发展为显性1型糖尿病的因素。我们根据当前数据重新审视了先前提出的用以解释1型糖尿病发病率增长的假说。最后，我们提出了一个统一模型，在该模型中，对β细胞的免疫耐受可被几种环境暴露打破，这些暴露诱导产生充当新自身抗原的杂合肽。
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本文引用的文献
1
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Lancet. 2016 Jun 4;387(10035):2331-2339. doi: 10.1016/S0140-6736(16)30582-7.
2
Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study.
Diabetes. 2016 Jul;65(7):1988-95. doi: 10.2337/db15-1180. Epub 2016 Mar 18.
3
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.
Science. 2016 Feb 12;351(6274):711-4. doi: 10.1126/science.aad2791.
4
Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes.
Diabetes. 2016 May;65(5):1362-9. doi: 10.2337/db15-1615. Epub 2016 Feb 8.
5
Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule.
Diabetes. 2016 Mar;65(3):732-41. doi: 10.2337/db15-1031. Epub 2015 Dec 30.
6
Infant Growth and Risk of Childhood-Onset Type 1 Diabetes in Children From 2 Scandinavian Birth Cohorts.
JAMA Pediatr. 2015 Dec;169(12):e153759. doi: 10.1001/jamapediatrics.2015.3759. Epub 2015 Dec 7.
7
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.
Cell Metab. 2016 Jan 12;23(1):179-93. doi: 10.1016/j.cmet.2015.10.016. Epub 2015 Nov 25.
8
Bacillus Calmette-Guérin (BCG) Vaccination in Infancy and Risk of Childhood Diabetes.
Paediatr Perinat Epidemiol. 2016 Mar;30(2):141-8. doi: 10.1111/ppe.12263. Epub 2015 Nov 20.
9
β cell ER stress and the implications for immunogenicity in type 1 diabetes.
Front Cell Dev Biol. 2015 Oct 27;3:67. doi: 10.3389/fcell.2015.00067. eCollection 2015.
10
Vaccinations and childhood type 1 diabetes mellitus: a meta-analysis of observational studies.
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