James Lisa M, Georgopoulos Apostolos P
The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, MN, 55417, USA.
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
J Immunol Sci. 2025 Aug 25;5(3):29-35. doi: 10.29245/2578-3009/2021/3.1219.
Human leukocyte antigen (HLA) is widely recognized to influence individual Type 1 diabetes (T1D) risk. Here we utilized an immunogenetic epidemiological approach to evaluate the influence of HLA on T1D at the population level. Specifically, we evaluated the correlations between the population frequencies of 127 HLA Class I and II alleles and the population prevalence of T1D in 14 Continental Western European countries to identify a population-level HLA profile for T1D. The results of these analyses generally corroborated prior findings regarding the influence of HLA on T1D risk and protection and revealed several novel HLA-T1D associations. The findings, discussed within the context of the role of HLA in pathogen elimination and autoimmunity, point to a contributory role of exposure to pathogens in the absence of protective HLA in underlying the autoimmune destruction of pancreatic beta cells in T1D.
人类白细胞抗原（HLA）对个体1型糖尿病（T1D）风险的影响已得到广泛认可。在此，我们采用免疫遗传学流行病学方法，在人群水平上评估HLA对T1D的影响。具体而言，我们评估了127种HLA I类和II类等位基因的人群频率与14个西欧大陆国家T1D的人群患病率之间的相关性，以确定T1D的人群水平HLA特征。这些分析结果总体上证实了先前关于HLA对T1D风险和保护作用影响的研究发现，并揭示了几种新的HLA-T1D关联。在HLA在病原体清除和自身免疫中的作用背景下讨论的这些发现表明，在缺乏保护性HLA的情况下接触病原体在T1D胰腺β细胞自身免疫性破坏中起促成作用。
