Verstockt Bram, Cleynen Isabelle
Department of Medicine and Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, UK; Translational Research in Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
Laboratory of Complex Genetics, Department of Human Genetics, KU Leuven , Leuven , Belgium.
Front Med (Lausanne). 2016 May 30;3:24. doi: 10.3389/fmed.2016.00024. eCollection 2016.
Fibrostenotic strictures are an important complication in patients with Crohn's disease (CD), very often necessitating surgery. This fibrotic process develops in a genetically susceptible individual and is influenced by an interplay with environmental, immunological, and disease-related factors. A deeper understanding of the genetic factors driving this fibrostenotic process might help to unravel the pathogenesis, and ultimately lead to development of new, anti-fibrotic therapy. Here, we review the genetic factors that have been associated with the development of fibrosis in patients with CD, as well as their potential pathophysiological mechanism(s). We also hypothesize on clinical implications, if any, and future research directions.
纤维狭窄性狭窄是克罗恩病(CD)患者的一种重要并发症,常常需要进行手术。这种纤维化过程在具有遗传易感性的个体中发生,并受到环境、免疫和疾病相关因素相互作用的影响。对驱动这种纤维狭窄过程的遗传因素有更深入的了解可能有助于阐明其发病机制,并最终促成新的抗纤维化疗法的开发。在此,我们综述了与CD患者纤维化发生相关的遗传因素及其潜在的病理生理机制。我们还对其临床意义(如有)及未来研究方向进行了推测。