Cho Judy H
Genetics and Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA.
Dig Dis. 2016;34(1-2):12-9. doi: 10.1159/000442919. Epub 2016 Mar 16.
Enrichment of GWAS signals within cell-specific enhancers defines cellular subsets most associated to IBD and highlights the critical role of epigenetics in IBD. We review the central role of the interleukin 23 (IL-23) pathway in cellular plasticity, mechanisms which are significantly mediated by epigenetic regulation of master transcription factors of various CD4+ T-cell subsets. Present studies need to be complemented by a deeper understanding of intestine-specific gene expression and epigenetics, especially in mononuclear phagocytes, given their enormous plasticity, and tissue-dependent function. A deeper understanding and application of epigenetics may impact and guide early treatment and ultimately, disease prevention in IBD.
全基因组关联研究（GWAS）信号在细胞特异性增强子中的富集确定了与炎症性肠病（IBD）最相关的细胞亚群，并突出了表观遗传学在IBD中的关键作用。我们综述了白细胞介素23（IL-23）通路在细胞可塑性中的核心作用，这些机制主要由各种CD4+T细胞亚群的主转录因子的表观遗传调控介导。鉴于单核吞噬细胞具有巨大的可塑性和组织依赖性功能，目前的研究需要通过更深入地了解肠道特异性基因表达和表观遗传学来加以补充。对表观遗传学的更深入理解和应用可能会影响并指导IBD的早期治疗，并最终实现疾病预防。
