Goldberg R A, Weisman J S, McFarland J E, Krauss H R, Hepler R S, Shorr N
Oculoplastics Division, Jules Stein Eye Institute, UCLA School of Medicine 90024-1771.
Arch Ophthalmol. 1989 Jun;107(6):831-5. doi: 10.1001/archopht.1989.01070010853028.
Three cases of long-standing intranasal cocaine abuse were associated with orbitopathy or optic neuropathy. All three cases were characterized by chronic sinusitis. Histopathologic examination of involved sinus and orbital tissues revealed chronic and acute nonspecific inflammation, with no evidence of unusual infections or of idiopathic midline destructive disease. In two of the cases, there was radiographic evidence of contiguous orbital inflammation associated with sinusitis. The inflammatory orbital process in these two cases was steroid responsive, but in one case recurrent inflammation occurred in response to steroid tapering. One patient suffered a complete loss of vision in the involved eye due to fulminant orbital inflammation and optic nerve dysfunction.
三例长期滥用鼻内可卡因的病例与眼眶病或视神经病变有关。所有三例均以慢性鼻窦炎为特征。对受累鼻窦和眼眶组织的组织病理学检查显示为慢性和急性非特异性炎症，未发现异常感染或特发性中线破坏性疾病的证据。其中两例有影像学证据表明存在与鼻窦炎相关的连续性眼眶炎症。这两例的眼眶炎症过程对类固醇有反应，但有一例在类固醇减量时出现复发性炎症。一名患者因暴发性眼眶炎症和视神经功能障碍导致患眼完全失明。
