School of Biological and Medical Engineering, Hefei University of Technology, Key Laboratory of Advanced Functional Materials and Devices of Anhui Province , Hefei 230009, P. R. China.
Org Lett. 2016 Jul 1;18(13):3114-7. doi: 10.1021/acs.orglett.6b01296. Epub 2016 Jun 15.
A novel catalyst-free decarboxylative amidation of α-keto acids with amines under mild conditions has been developed. Advantages of the new protocol include avoidance of metal catalysts and high levels of functional group tolerance. In addition, the reaction can be scaled up and shows high chemoselectivity. Preliminary mechanistic studies suggest that singlet oxygen, generated from oxygen under irradiation, is the key promoter for this catalyst-free transformation.
发展了一种在温和条件下无催化剂的α-酮酸与胺的脱羧酰胺化反应。新反应的优点包括避免使用金属催化剂和对官能团具有高容忍度。此外，该反应可以放大规模，并表现出高的化学选择性。初步的机理研究表明，光照下氧气产生的单线态氧是这种无催化剂转化的关键促进剂。
