急性淋巴细胞白血病红细胞膜的异常
Abnormalities in the erythrocyte membrane in acute lymphoid leukaemia.
作者信息
Kundu M, Basu J, Chakrabarti P, Rakshit M M
机构信息
Department of Chemistry, Bose Institute, Calcutta, India.
出版信息
Biochem J. 1989 Mar 15;258(3):903-6. doi: 10.1042/bj2580903.
Erythrocytes from patients suffering from acute lymphoid leukaemia (ALL) show decreased proportions of spectrin tetrameters and altered spatial distribution of band 4.1 and ankyrins. These abnormalities of the cytoskeleton are probably responsible for altered membrane fluidity and transbilayer distribution of phosphatidylethanolamine in ALL. ALL is associated with severe anaemia and usually, but not always, with overproduction of lymphocytes. To our knowledge, this is the first report of abnormalities in the erythrocyte membrane in ALL which may, in part, be responsible for the observed anaemia.
急性淋巴细胞白血病（ALL）患者的红细胞显示血影蛋白四聚体比例降低，以及带4.1和锚蛋白的空间分布改变。细胞骨架的这些异常可能是ALL中膜流动性改变和磷脂酰乙醇胺跨膜分布改变的原因。ALL与严重贫血有关，通常（但并非总是）伴有淋巴细胞过度生成。据我们所知，这是关于ALL患者红细胞膜异常的首次报告，这些异常可能部分导致了观察到的贫血。
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