Schneider W, Grune T, Siems W, Werner A, Gerber G
Institut für Biochemie, Bereich Medizin Charité, Humboldt-Universität, Berlin, DDR.
Biomed Biochim Acta. 1989;48(2-3):S40-3.
In hepatocytes of starved rats nucleotide, nucleoside and nucleobase concentrations were measured during and following anoxia. A complete restoration of ATP is observed during reoxygenation after anoxic periods less than 60 minutes. GTP cannot be completely restored after 30 minutes of anoxia. Allopurinol and oxypurinol do not accelerate the ATP and GTP restoration. IMP, adenosine and AMP concentrations are increased in presence of allopurinol or oxypurinol during anoxia and reoxygenation.
在饥饿大鼠的肝细胞中，在缺氧期间及之后测量了核苷酸、核苷和核碱基的浓度。在缺氧时间少于60分钟后的复氧过程中，观察到ATP完全恢复。缺氧30分钟后，GTP不能完全恢复。别嘌呤醇和氧嘌呤醇不会加速ATP和GTP的恢复。在缺氧和复氧期间，别嘌呤醇或氧嘌呤醇存在时，IMP、腺苷和AMP的浓度会增加。
