Numazawa M, Mutsumi A, Hoshi K, Koike R
Tohoku College of Pharmacy, Sendai, Japan.
Biochem Biophys Res Commun. 1989 May 15;160(3):1009-14. doi: 10.1016/s0006-291x(89)80102-0.
3-Deoxy steroids having a 4-ene system were found to be competitive inhibitors of human placental aromatase. 19-Hydroxy-4-androsten-17-one (2) potently inhibits the enzyme with an apparent Ki of 12.5 nM, but does not produce a time-dependent inactivation of the enzyme.
具有4-烯体系的3-脱氧类固醇被发现是人类胎盘芳香化酶的竞争性抑制剂。19-羟基-4-雄烯-17-酮（2）能有效抑制该酶，其表观抑制常数（Ki）为12.5 nM，但不会导致该酶的时间依赖性失活。
