Muñoz Laura, Santin Miguel
1 Tuberculosis Unit, Service of Infectious Diseases, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. 2 Department of Clinical Sciences, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Transplantation. 2016 Sep;100(9):1840-52. doi: 10.1097/TP.0000000000001224.
Transplant recipients are at increased risk for tuberculosis (TB), which can adversely affect graft viability and patient survival. Scientific societies and official organizations have therefore issued guidelines and consensus statements for TB prevention and treatment. However, due to the poor supporting evidence, the current recommendations largely rely on expert opinion rather than on properly designed studies. In this overview, we aim to gather together the previous experience and compare and contrast the main current guidelines on the prevention and treatment of TB in solid organ transplantation and hematopoietic stem cell transplantation.
移植受者患结核病(TB)的风险增加,这可能会对移植物的存活能力和患者的生存率产生不利影响。因此,科学协会和官方组织已发布了结核病预防和治疗的指南及共识声明。然而,由于支持证据不足,目前的建议很大程度上依赖专家意见而非精心设计的研究。在本综述中,我们旨在汇总以往的经验,并比较和对照目前关于实体器官移植和造血干细胞移植中结核病预防和治疗的主要指南。