Clemente Wanessa T, Faria Luciana C, Cota Gláucia F, Amado Leandro Ricardo de Navarro, Oliveira Jaqueline G F, de Miranda Silvana Spíndola, Cançado Omar Lopes, Romanelli Roberta M C, Lima Agnaldo S, Frade Luiza Bastos, Lucas Fernando, Sanches Marcelo Dias
Alfa Institute of Gastroenterology - Liver Transplant Program, Hospital das Clínicas/UFMG, Brazil.
Laboratory Medicine Department, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Brazil.
Case Rep Transplant. 2021 Apr 17;2021:8816426. doi: 10.1155/2021/8816426. eCollection 2021.
Donor-derived tuberculosis (DD-TB) accounts for less than 5% of TB cases and is considered a rare event. In the transplant setting, the frequency of active TB is estimated to be 20 to 74 times higher than that in the general population, and it is associated with high mortality. In this context, the main strategy to minimize the risk of DD transmission is to identify high-risk donors. Despite screening recommendations, failures may result in a breakdown of safety that ends in the transmission of potentially fatal diseases. This report describes a case of DD-TB and emphasizes communication gaps that may occur between organ procurement organizations and transplant centers. Failure in reporting results, lack of exchanging information regarding recipients from the same donor, and inefficient communication between organ procurement organizations and transplant centers are lacks that may be prevented by a more efficient approach towards screening protocols and communication.
供体来源的结核病（DD-TB）占结核病病例的比例不到5%，被认为是罕见事件。在移植环境中，活动性结核病的发生率估计比普通人群高20至74倍，且与高死亡率相关。在这种情况下，将DD传播风险降至最低的主要策略是识别高风险供体。尽管有筛查建议，但仍可能出现失误，导致安全漏洞，最终致使潜在致命疾病传播。本报告描述了一例DD-TB病例，并强调了器官获取组织与移植中心之间可能出现的沟通差距。报告结果失败、缺乏关于同一供体受者的信息交流以及器官获取组织与移植中心之间沟通效率低下等问题，可通过采用更有效的筛查方案和沟通方法加以避免。
