Katz Morgan J, Roghmann Mary-Claire
aJohns Hopkins University, Department of Medicine, Division of Infectious Disease bDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Geriatrics Research Education and Clinical Center, VA Maryland Healthcare System, Baltimore, Maryland, USA.
Curr Opin Infect Dis. 2016 Aug;29(4):388-93. doi: 10.1097/QCO.0000000000000283.
The high-risk population and current lack of knowledge regarding appropriate infection prevention in the long-term care (LTC) setting has contributed to substantial rates of resistance and healthcare-associated infections in this arena. More evidence-based research on LTC is necessary, particularly now that the elderly population is increasing.
Proposed government mandates highlight the urgent need to combat antimicrobial resistance in the LTC setting. Recent studies focusing on unique strategies for the prevention of transmission and infection with multidrug-resistant organisms in nursing homes are discussed, as well as attempts to formulate clear antimicrobial stewardship programs.
The long-term setting has unique challenges to instituting effective infection control precautions, therefore current accepted methods used in acute-care facilities need to be modified. Recent data suggest that prevention of transmission in LTC may be achieved with focus on high-risk patients or specific care-based activities rather than colonization status. Antimicrobial stewardship and consultation with specialized physicians may be important measures to combat resistance and adverse events in LTC. The prevention of unnecessary antibiotic use in palliative care may reduce rates of resistance as well as discomfort for terminal patients.
长期护理(LTC)环境中的高危人群以及目前对适当感染预防知识的缺乏,导致了该领域中耐药率和医疗相关感染率居高不下。鉴于老年人口不断增加,有必要开展更多基于证据的长期护理研究。
拟议的政府指令凸显了在长期护理环境中对抗抗菌药物耐药性的迫切需求。本文讨论了近期聚焦于养老院预防多重耐药菌传播和感染的独特策略的研究,以及制定明确的抗菌药物管理计划的尝试。
长期护理环境在实施有效的感染控制预防措施方面面临独特挑战,因此需要对目前在急性护理机构中采用的公认方法进行调整。近期数据表明,通过关注高危患者或特定的护理活动而非定植状态,可能实现长期护理环境中的传播预防。抗菌药物管理以及与专科医生的会诊可能是对抗长期护理环境中的耐药性和不良事件的重要措施。在姑息治疗中预防不必要的抗生素使用可能会降低耐药率,并减轻晚期患者的不适。