日本接受无创产前检测的夫妇背景。

Background of couples undergoing non-invasive prenatal testing in Japan.

作者信息

Takeda Eri, Suzumori Nobuhiro, Kumagai Kyoko, Oseto Kumiko, Ebara Takeshi, Yotsumoto Junko, Numabe Hironao, Sugiura-Ogasawara Mayumi

机构信息

Department of Obstetrics and Gynecology, Nagoya City University, Tokyo, Japan.

Department of Genetic Counseling, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan.

出版信息

J Obstet Gynaecol Res. 2016 Oct;42(10):1222-1228. doi: 10.1111/jog.13041. Epub 2016 Jun 16.

DOI:10.1111/jog.13041

PMID:27306835

Abstract

AIM

Our purpose was to assess the background of couples who were undergoing non-invasive prenatal testing (NIPT) in Japan.

METHODS

The characteristics of 2486 women who had visited Nagoya City University Hospital for NIPT were compared with Japanese Demographic Trends as controls. The questionnaire included items regarding the maternal and paternal age, maternal age at marriage, age at first live birth, and conception mode.

RESULTS

Compared with the controls, the percentage of women who were 4 or more years older than their partners was larger in the NIPT group (11.8% vs 6.5%). The maternal age at marriage, age at first live birth, and the duration between marriage and first birth tended to be greater in the NIPT group (32.6 years vs 29.3 years, 36.9 years vs 30.4 years, and 3.6 years vs 2.4 years, respectively), and the percentage of women who underwent assisted reproductive technology tended to be higher in the NIPT group (35-39 years: 21.2% vs 7.5%, 40-45 years: 36.2% vs 12.6%), compared with the controls.

CONCLUSION

Knowing the specific backgrounds of couples who have undergone NIPT may be important for improving the quality of genetic counseling for NIPT.

摘要

目的

我们的目的是评估在日本接受无创产前检测（NIPT）的夫妇的背景情况。

方法

将2486名到名古屋市立大学医院接受NIPT的女性的特征与作为对照的日本人口趋势进行比较。调查问卷包括有关父母年龄、母亲结婚年龄、首次生育年龄和受孕方式的项目。

结果

与对照组相比，NIPT组中女性比伴侣大4岁或以上的比例更高（11.8%对6.5%）。NIPT组的母亲结婚年龄、首次生育年龄以及结婚与首次生育之间的间隔往往更大（分别为32.6岁对29.3岁、36.9岁对30.4岁、3.6岁对2.4岁），并且与对照组相比，NIPT组中接受辅助生殖技术的女性比例往往更高（35 - 39岁：21.2%对7.5%，40 - 45岁：36.2%对12.6%）。