因高龄产妇接受无创产前检测的女性的非特异性心理困扰

Non-specific psychological distress in women undergoing noninvasive prenatal testing because of advanced maternal age.

作者信息

Suzumori Nobuhiro, Ebara Takeshi, Kumagai Kyoko, Goto Shinobu, Yamada Yasuyuki, Kamijima Michihiro, Sugiura-Ogasawara Mayumi

机构信息

Division of Clinical and Molecular Genetics, Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

出版信息

Prenat Diagn. 2014 Nov;34(11):1055-60. doi: 10.1002/pd.4427. Epub 2014 Jun 29.

DOI:10.1002/pd.4427

PMID:24894736

Abstract

OBJECTIVE

The objective of our study was to describe our clinical experience in providing noninvasive prenatal testing (NIPT) for fetal aneuploidy to pregnant women, highlighting the degree of non-specific psychological distress.

METHODS

Data were collected from Japanese women who were offered and underwent NIPT after genetic counseling and control pregnant women who did not undergo NIPT as part of the Japan Environment and Children's Study Control A planning. The degree of mental distress was assessed using the Kessler 6 (K6) screening scale with a score of ≥10 indicating depression or anxiety disorder.

RESULTS

Among the 505 women who underwent NIPT because of advanced maternal age, 9.1% had a K6 score of ≥10. Compared with matched controls (n = 1010) adjusted for maternal age and gestational age, the NIPT group showed a trend toward higher K6 scores (odds ratio 1.44, 95% confidence interval 0.97-2.13, P = 0.07). Higher K6 scores were associated with women whose husbands were the primary decision makers during NIPT counseling (P = 0.06).

CONCLUSIONS

Women electing NIPT tend to have higher scores of depression/anxiety, and those with higher depression scores tended to defer the decision to their husbands.

摘要

目的

我们研究的目的是描述为孕妇提供胎儿非整倍体无创产前检测（NIPT）的临床经验，重点关注非特异性心理困扰程度。

方法

数据收集自接受遗传咨询后接受NIPT的日本女性以及作为日本环境与儿童研究对照A计划一部分未接受NIPT的对照孕妇。使用凯斯勒6项量表（K6）评估心理困扰程度，得分≥10表明患有抑郁症或焦虑症。

结果

在因母亲年龄较大而接受NIPT的505名女性中，9.1%的K6得分≥10。与根据母亲年龄和孕周进行匹配的对照组（n = 1010）相比，NIPT组K6得分有升高趋势（优势比1.44，95%置信区间0.97 - 2.13，P = 0.07）。K6得分较高与在NIPT咨询期间丈夫是主要决策者的女性相关（P = 0.06）。