Medical Imaging Department, Princess Alexandra Hospital, Brisbane, Australia
School of Medicine, University of Queensland, Brisbane, Australia.
J Nucl Med. 2016 Nov;57(11):1733-1739. doi: 10.2967/jnumed.115.169870. Epub 2016 Jun 15.
Our aim was to determine the feasibility of F-florbetaben PET in diagnosing cardiac amyloidosis.
F-florbetaben PET was performed on 14 patients: 5 amyloid light chain, 5 amyloid transthyretin, and 4 control with hypertensive heart disease. Qualitative and quantitative assessments of F-florbetaben activity were performed using the SUV of the left ventricular myocardium and blood pool and calculation of target-to-background SUV ratio. Myocardial F-forbetaben retention was also calculated as the percentage mean myocardial SUV change between 0 and 5 min and 15 and 20 min after radiotracer injection. Global left ventricular longitudinal and right ventricular free wall longitudinal strain were calculated using 2-dimensional speckle-tracking echocardiography.
Target-to-background SUV ratio and percentage myocardial F-forbetaben retention were higher in amyloid patients than in hypertensive controls. A cutoff of 40% was able to differentiate between cardiac amyloid patients and hypertensive controls. Percentage myocardial F-forbetaben retention was an independent determinant of both global left ventricular longitudinal and right ventricular free wall longitudinal strain via an inverse curve relationship.
F-florbetaben PET imaging can accurately identify and differentiate between cardiac amyloidosis and hypertensive heart disease. Percentage myocardial F-florbetaben retention was an independent determinant of myocardial dysfunction in cardiac amyloidosis.
确定 F-氟比洛芬 PET 诊断心脏淀粉样变性的可行性。
对 14 例患者进行 F-氟比洛芬 PET 检查：5 例淀粉样轻链，5 例淀粉样转甲状腺素，4 例高血压性心脏病对照。使用左心室心肌和血池的 SUV 以及靶与背景 SUV 比值进行 F-氟比洛芬活性的定性和定量评估。还计算了心肌 F-氟比洛芬保留率，即放射性示踪剂注射后 0 至 5 分钟和 15 至 20 分钟之间心肌 SUV 变化的平均百分比。使用二维斑点追踪超声心动图计算左心室整体长轴和右心室游离壁长轴应变。
淀粉样患者的靶与背景 SUV 比值和心肌 F-氟比洛芬保留率高于高血压对照组。40%的截值可区分心脏淀粉样变性患者和高血压对照组。心肌 F-氟比洛芬保留率通过反曲线关系是左心室整体长轴和右心室游离壁长轴应变的独立决定因素。
F-氟比洛芬 PET 成像可准确识别和区分心脏淀粉样变性和高血压性心脏病。心肌 F-氟比洛芬保留率是心脏淀粉样变性心肌功能障碍的独立决定因素。
