Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Clin Cancer Res. 2016 Aug 15;22(16):3987-8. doi: 10.1158/1078-0432.CCR-16-1043. Epub 2016 Jun 15.
Sequencing for somatic alterations in patients' tumors is being increasingly clinically implemented to detect mutations that may guide therapy. Germline analysis of a cohort of patients undergoing tumor sequencing with matched normal has revealed that a small but significant percentage of these patients have germline variants that confer cancer susceptibility. Clin Cancer Res; 22(16); 3987-8. ©2016 AACRSee related article by Seifert et al., p. 4087.
对患者肿瘤的体细胞改变进行测序，正越来越多地被临床实施，以检测可能指导治疗的突变。对接受肿瘤测序并匹配正常组织的患者队列进行种系分析，揭示了一小部分但具有显著意义的这些患者存在种系变异，赋予其癌症易感性。临床癌症研究；22（16）；3987-8. ©2016AACR 参见 Seifert 等人的相关文章，第 4087 页。
