Santucci M, Urso C, Giannini A, Bondi R
Istituto di Anatomia e Istologia Patologia, Università di Firenze, Italia.
Appl Pathol. 1989;7(2):111-5.
Nuclei of melanocytes in 10 common acquired melanocytic nevi, 10 malignant melanomas and 10 dysplastic melanocytic nevi (melanocytic dysplasia) (MD) were morphometrically analyzed. MD group consisted of 6 lesions with (MD 1) and 4 without (MD 2) the clinical features of dysplastic nevi. The considered parameters were area, perimeter and form Ar. In the MD group, the results showed that median values of each considered parameter of MD 1 were close to those of MD 2. For each evaluated parameter, median values of MD turned out to be intermediate between those of common acquired melanocytic nevi and of malignant melanomas. Confirming the histologic evidence of a double - nonatypical and atypical - melanocytic population in melanocytic dysplasia, our data showed that nonatypical melanocytes were indistinguishable from melanocytes of common acquired nevi, while the atypical melanocytes were close to melanoma cells. The importance of atypical melanocytes is stressed in the diagnosis of melanocytic dysplasia.
对10例常见获得性黑素细胞痣、10例恶性黑素瘤和10例发育异常性黑素细胞痣（黑素细胞发育异常，MD）的黑素细胞进行了形态计量分析。MD组包括6例具有（MD 1）和4例不具有（MD 2）发育异常痣临床特征的病变。所考虑的参数为面积、周长和形态学参数Ar。在MD组中，结果显示MD 1各所考虑参数的中位数与MD 2接近。对于每个评估参数，MD的中位数结果介于常见获得性黑素细胞痣和恶性黑素瘤之间。我们的数据证实了黑素细胞发育异常中存在双重非典型和非典型黑素细胞群体的组织学证据，表明非典型黑素细胞与常见获得性痣的黑素细胞无法区分，而非典型黑素细胞则与黑素瘤细胞相似。非典型黑素细胞在黑素细胞发育异常的诊断中具有重要意义。
