SAT1与多形性胶质母细胞瘤：消除耐药性。
SAT1 and glioblastoma multiforme: Disarming the resistance.
作者信息
Brett-Morris Adina, Mislmani Mazen, Welford Scott M
机构信息
Department of Radiation Oncology; School of Medicine; Case Western Reserve University ; 10900 Euclid Avenue; Cleveland, OH USA.
出版信息
Mol Cell Oncol. 2015 Jan 23;2(3):e983393. doi: 10.4161/23723556.2014.983393. eCollection 2015 Jul-Sep.
Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.
多形性胶质母细胞瘤是最常见且最具危害性的脑肿瘤形式，目前的生存时间短至仅14个月。我们最近发现了一种基于多胺分解代谢酶亚精胺/精胺N1 - 乙酰转移酶过表达的治疗耐药新机制，该酶通过染色质修饰促进DNA修复。
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