Fbw7与Usp28——对手与盟友
Fbw7 and Usp28 - enemies and allies.
作者信息
Taranets Lyudmyla, Zhu Jing, Xu Wenshan, Popov Nikita
机构信息
Comprehensive Cancer Center Mainfranken and Department of Radiation Oncology; University Hospital Würzburg ; Würzburg, Germany.
出版信息
Mol Cell Oncol. 2015 Jan 23;2(3):e995041. doi: 10.4161/23723556.2014.995041. eCollection 2015 Jul-Sep.
The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regulation of Fbw7 activity and tumor development.
泛素特异性蛋白酶28（Usp28）去泛素化酶可对抗Fbw7介导的多种癌蛋白（包括Myc、Jun和Notch）的周转，并促进肠道肿瘤发生。我们最近的研究表明，Usp28还可抵消Fbw7的自催化泛素化作用，提示Usp28在Fbw7活性调节和肿瘤发展中发挥复杂作用。
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