Shalini Sonia, Kumar Sharad
Center for Cancer Biology; University of South Australia ; Adelaide, SA, Australia.
Mol Cell Oncol. 2015 Jan 23;2(4):e1004956. doi: 10.1080/23723556.2015.1004956. eCollection 2015 Oct-Dec.
Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status and activating the antioxidant defense system. These apparent non-apoptotic functions, only discovered recently, emphasize the importance of this often-neglected protease.
半胱天冬酶-2是最早发现的半胱天冬酶之一，已成为一种多功能酶，其作用不仅限于细胞死亡。它作为一种肿瘤抑制因子，可防止基因不稳定，并通过在感知细胞氧化还原状态变化和激活抗氧化防御系统中发挥关键作用来抵御衰老。这些直到最近才被发现的明显的非凋亡功能，凸显了这种常被忽视的蛋白酶的重要性。
