CD300受体在调节髓样细胞胞葬作用中的新作用。
Emerging role of CD300 receptors in regulating myeloid cell efferocytosis.
作者信息
Voss Oliver H, Tian Linjie, Murakami Yousuke, Coligan John E, Krzewski Konrad
机构信息
Receptor Cell Biology Section; Laboratory of Immunogenetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Rockville, MD, USA.
出版信息
Mol Cell Oncol. 2015 Jun 5;2(4):e964625. doi: 10.4161/23723548.2014.964625. eCollection 2015 Oct-Dec.
Engulfment of apoptotic cells is predominantly executed by phagocytes via the recognition of "eat me" signals like phosphatidylserine (PS). Various PS-specific receptors exist on phagocytes, including Tyro3, Axl, and MerTK receptor tyrosine kinases (TAMs), T-cell immunoglobulin and mucin domain containing 1 and 4 (TIM1/4), and the newly identified CD300 family. The aim of the present auto-commentary is to highlight recent findings regarding the Cd300lf and Cd300lb receptors and their emerging roles in the development of autoimmune disease.
凋亡细胞的吞噬主要由吞噬细胞通过识别“吃我”信号（如磷脂酰丝氨酸（PS））来执行。吞噬细胞上存在多种PS特异性受体，包括酪氨酸激酶受体Tyro3、Axl和MerTK（TAM家族）、含T细胞免疫球蛋白和粘蛋白结构域1和4（TIM1/4）以及新发现的CD300家族。本自动评论的目的是强调关于Cd300lf和Cd300lb受体的最新发现及其在自身免疫性疾病发展中的新作用。
Zotero 插件