p85α 新形态突变体：脱离经典途径
p85α neomorphic mutants: splitting away from the canonical path.
作者信息
Cheung Lydia Wt, Mills Gordon B
机构信息
Department of Systems Biology; University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
出版信息
Mol Cell Oncol. 2015 May 27;2(4):e983388. doi: 10.4161/23723556.2014.983388. eCollection 2015 Oct-Dec.
Abstract
PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.
摘要
PIK3R1（编码磷脂酰肌醇3-激酶的p85α亚基）是各类肿瘤中第11个最常发生突变的基因。我们最近报道了新型p85α突变体，它们可诱导p85α的经典功能未预测到的信号级联反应，这表明需要对癌症基因中的特定突变进行功能注释，以实现有效的基于基因组信息的个性化治疗。
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