细菌对上皮细胞死亡和存活的双面调控：与结肠癌发生的关联。
Janus-faced bacterial regulation of epithelial cell death and survival: Association with colon carcinogenesis.
作者信息
Kuo Wei-Ting, Lee Tsung-Chun, Yu Linda Chia-Hui
机构信息
Graduate Institute of Physiology, National Taiwan University College of Medicine.
Graduate Institute of Physiology, National Taiwan University College of Medicine; Department of Internal Medicine; National Taiwan University Hospital; Taipei, Taiwan, ROC.
出版信息
Mol Cell Oncol. 2015 Sep 16;3(1):e1029064. doi: 10.1080/23723556.2015.1029064. eCollection 2016 Jan.
Abstract
Gut microbiota and lipopolysaccharide (LPS) signaling have been associated with colon cancer development. Our recent findings demonstrated that LPS receptor subunits expressed on colonocytes have antagonistic roles in cell death and tumorigenesis: epithelial toll-like receptor 4 (TLR4) confers resistance to the apoptosis induced by its co-receptor CD14 and contributes to epithelial transition to cancer.
摘要
肠道微生物群和脂多糖（LPS）信号传导与结肠癌的发生有关。我们最近的研究结果表明，结肠细胞上表达的LPS受体亚基在细胞死亡和肿瘤发生中具有拮抗作用：上皮 toll 样受体 4（TLR4）赋予对其共受体 CD14 诱导的细胞凋亡的抗性，并促进上皮向癌症的转变。
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