化学解析：使用选择性BCL-2家族抑制剂工具包剖析细胞依赖性
Chemical parsing: Dissecting cell dependencies with a toolkit of selective BCL-2 family inhibitors.
作者信息
Leverson Joel D
机构信息
Oncology Development , AbbVie, Chicago, IL, USA.
出版信息
Mol Cell Oncol. 2015 May 26;3(1):e1050155. doi: 10.1080/23723556.2015.1050155. eCollection 2016 Jan.
Abstract
The BCL-2/BCL-XL inhibitor navitoclax has shown promise for the treatment of cancer but on-target toxicities have limited its utility. Recently, the generation of selective BCL-2 family inhibitors has enabled a careful dissection of BCL-2 biology, and early work indicates that these molecules have improved therapeutic profiles for the treatment of cancer.
摘要
BCL-2/BCL-XL抑制剂navitoclax在癌症治疗方面已显示出前景，但靶向毒性限制了其应用。最近，选择性BCL-2家族抑制剂的产生使得对BCL-2生物学特性能够进行细致剖析，早期研究表明这些分子在癌症治疗方面具有更好的治疗效果。
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