当守护者变成敌人：在PTEN缺陷型癌症中靶向ATM
When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers.
作者信息
McCabe Nuala, Walker Steven M, Kennedy Richard D
机构信息
Centre for Cancer Research and Cell Biology, Queens University Belfast, Northern Ireland; Almac Diagnostics, Craigavon, Northern Ireland.
出版信息
Mol Cell Oncol. 2015 Jun 10;3(1):e1053595. doi: 10.1080/23723556.2015.1053595. eCollection 2016 Jan.
Abstract
Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response and inhibitors of ATM are under clinical development. We identified a synthetic lethal interaction between ATM inhibition and phosphatase and tensin homolog (PTEN) loss that was the result of increased oxidative stress. Inhibition of ATM therefore represents a novel strategy to target PTEN-associated cancers.
摘要
共济失调毛细血管扩张症突变基因（ATM）是DNA损伤反应中的一种重要信号分子，ATM抑制剂正处于临床开发阶段。我们发现ATM抑制与磷酸酶和张力蛋白同源物（PTEN）缺失之间存在合成致死相互作用，这是氧化应激增加的结果。因此，抑制ATM代表了一种针对PTEN相关癌症的新策略。
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