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Mol Cell Oncol. 2015 Sep 11;3(2):e1079673. doi: 10.1080/23723556.2015.1079673. eCollection 2016 Mar.
2
The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.在神经细胞增殖过程中，MRN复合物受MYCN转录调控，以控制复制应激。
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本文引用的文献

1
The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.在神经细胞增殖过程中，MRN复合物受MYCN转录调控，以控制复制应激。
Cell Death Differ. 2016 Feb;23(2):197-206. doi: 10.1038/cdd.2015.81. Epub 2015 Jun 12.
2
Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.设想Mre11-Rad50-Nbs1复合物的动力学和灵活性，以解读其在DNA复制和修复中的作用。
Prog Biophys Mol Biol. 2015 Mar;117(2-3):182-193. doi: 10.1016/j.pbiomolbio.2014.12.004. Epub 2015 Jan 7.
3
Myc induced replicative stress response: How to cope with it and exploit it.Myc诱导的复制应激反应：如何应对及加以利用。
Biochim Biophys Acta. 2015 May;1849(5):517-24. doi: 10.1016/j.bbagrm.2014.04.008. Epub 2014 Apr 13.
4
The essential function of the MRN complex in the resolution of endogenous replication intermediates.MRN 复合物在解决内源性复制中间体中的基本功能。
Cell Rep. 2014 Jan 16;6(1):182-95. doi: 10.1016/j.celrep.2013.12.018. Epub 2014 Jan 2.
5
Maintaining genome stability in the nervous system.维持神经系统中的基因组稳定性。
Nat Neurosci. 2013 Nov;16(11):1523-9. doi: 10.1038/nn.3537. Epub 2013 Oct 28.
6
Nijmegen breakage syndrome (NBS).尼曼匹克破碎综合征（NBS）。
Orphanet J Rare Dis. 2012 Feb 28;7:13. doi: 10.1186/1750-1172-7-13.
7
The MRE11 complex: starting from the ends.MRE11 复合物：从末端开始。
Nat Rev Mol Cell Biol. 2011 Feb;12(2):90-103. doi: 10.1038/nrm3047.
8
Genotype-phenotype correlations in MYCN-related Feingold syndrome.与MYCN相关的费因戈尔德综合征的基因型-表型相关性
Hum Mutat. 2008 Sep;29(9):1125-32. doi: 10.1002/humu.20750.
9
An essential function for NBS1 in the prevention of ataxia and cerebellar defects.NBS1在预防共济失调和小脑缺陷中的重要作用。
Nat Med. 2005 May;11(5):538-44. doi: 10.1038/nm1228. Epub 2005 Apr 10.
10
N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.N-myc在神经发生过程中对于祖细胞群体的快速扩增和神经元分化的抑制至关重要。
Genes Dev. 2002 Oct 15;16(20):2699-712. doi: 10.1101/gad.1021202.

一个MYCN-MRN复合物轴控制复制应激，以实现神经祖细胞的安全扩增。

A MYCN-MRN complex axis controls replication stress for the safe expansion of neuroprogenitor cells.

作者信息

Petroni Marialaura, Giannini Giuseppe

机构信息

Dept. Molecular Medicine, University La Sapienza , Rome.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dept. Molecular Medicine, University La Sapienza , Rome, Italy.

出版信息

Mol Cell Oncol. 2015 Sep 11;3(2):e1079673. doi: 10.1080/23723556.2015.1079673. eCollection 2016 Mar.

DOI:10.1080/23723556.2015.1079673
PMID:27308604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4905383/
Abstract

DNA replication must be tightly regulated to ensure accurate duplication of the genome and its transfer to the daughter cells. When these regulatory mechanisms fail, replicative stress and DNA damage ensue, eventually leading to cell cycle inhibition or cell death. We have recently uncovered that MYCN-dependent expansion of neuroprogenitor cells is accompanied by replication stress, which is restrained by the MRN complex, a direct transcriptional target of the MYCN proto-oncogene.

摘要

DNA复制必须受到严格调控，以确保基因组的准确复制及其向子细胞的传递。当这些调控机制失效时，就会产生复制应激和DNA损伤，最终导致细胞周期抑制或细胞死亡。我们最近发现，神经祖细胞的MYCN依赖性扩增伴随着复制应激，而这种应激受到MRN复合物的抑制，MRN复合物是MYCN原癌基因的直接转录靶点。