Autophagy degrades hypoxia inducible factors.
作者信息
DePavia Adela, Jonasch Eric, Liu Xian-De
机构信息
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
出版信息
Mol Cell Oncol. 2016 Mar 16;3(2):e1104428. doi: 10.1080/23723556.2015.1104428. eCollection 2016 Mar.
Abstract
Hypoxia inducible factors are subjected to degradation by the ubiquitin-proteasome system (UPS), macroautophagy, and chaperone-mediated autophagy. The E3 ligases, ubiquitination, autophagy receptor proteins, and oxygen are determinants that direct hypoxia-inducible factors to different degradation pathways.
摘要
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