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扩展的m正则线性栈的枚举

Enumeration of Extended m-Regular Linear Stacks.

作者信息

Guo Qiang-Hui, Sun Lisa H, Wang Jian

机构信息

Center for Combinatorics, LPMC-TJKLC, Nankai University , Tianjin, P.R. China .

出版信息

J Comput Biol. 2016 Dec;23(12):943-956. doi: 10.1089/cmb.2016.0041. Epub 2016 Jun 16.

Abstract

The contact map of a protein fold in the two-dimensional (2D) square lattice has arc length at least 3, and each internal vertex has degree at most 2, whereas the two terminal vertices have degree at most 3. Recently, Chen, Guo, Sun, and Wang studied the enumeration of [Formula: see text]-regular linear stacks, where each arc has length at least [Formula: see text] and the degree of each vertex is bounded by 2. Since the two terminal points in a protein fold in the 2D square lattice may form contacts with at most three adjacent lattice points, we are led to the study of extended [Formula: see text]-regular linear stacks, in which the degree of each terminal point is bounded by 3. This model is closed to real protein contact maps. Denote the generating functions of the [Formula: see text]-regular linear stacks and the extended [Formula: see text]-regular linear stacks by [Formula: see text] and [Formula: see text], respectively. We show that [Formula: see text] can be written as a rational function of [Formula: see text]. For a certain [Formula: see text], by eliminating [Formula: see text], we obtain an equation satisfied by [Formula: see text] and derive the asymptotic formula of the numbers of [Formula: see text]-regular linear stacks of length [Formula: see text].

摘要

蛋白质折叠在二维(2D)方格晶格中的接触图的弧长至少为3,并且每个内部顶点的度数至多为2,而两个终端顶点的度数至多为3。最近,陈、郭、孙和王研究了[公式:见原文]-正则线性堆叠的计数问题,其中每条弧的长度至少为[公式:见原文]且每个顶点的度数受限于2。由于二维方格晶格中蛋白质折叠的两个端点最多可与三个相邻晶格点形成接触,我们进而研究扩展的[公式:见原文]-正则线性堆叠,其中每个端点的度数受限于3。该模型与实际蛋白质接触图相近。分别用[公式:见原文]和[公式:见原文]表示[公式:见原文]-正则线性堆叠和扩展的[公式:见原文]-正则线性堆叠的生成函数。我们证明[公式:见原文]可以写成[公式:见原文]的有理函数。对于某个[公式:见原文],通过消去[公式:见原文],我们得到一个由[公式:见原文]满足的方程,并推导出长度为[公式:见原文]的[公式:见原文]-正则线性堆叠数量的渐近公式。

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